在晚期艾滋病患者中对人类免疫缺陷病毒的被动免疫中和
G G Jackson1, J T Perkins, M Rubenis
1Department of Medicine, University of Illinois, College of Medicine, Chicago.
Lancet (London, England)
|September 17, 1988
概括
高抗体血输液迅速清除了晚期艾滋病患者的人类免疫缺陷病毒 (HIV) 抗原血症. 这种被动抗体疗法提供了持续的HIV中和,并减少了几周的机会性感染.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 先进的获得性免疫缺陷综合征 (艾滋病) 具有高水平的人类免疫缺陷病毒 (HIV) 和免疫缺陷的特征.
- 目前的治疗方法可能无法完全控制病毒载量或在所有患者中预防机会性感染.
研究的目的:
- 在患有晚期艾滋病的患者中,评估使用高抗HIV抗体标位的捐赠者血的被动抗体治疗的疗效.
- 评估血输注对病毒载量,免疫状态和临床结果的影响.
主要方法:
- 六名患有晚期艾滋病的患者接受了高抗p24抗体标位和中和能力的供体的血输液 (55-500毫升).
- 监测包括评估艾滋病毒抗原血症,受体抗体概况,艾滋病毒中和,T淋巴细胞计数和机会性感染频率.
主要成果:
- 输液后观察到HIV抗原血症的立即清除.
- 接受者获得了捐赠者的HIV抗体配置文件,并证明了HIV中和活性.
- 被动抗体效应持续长达11周,血半衰期约为12天.
- 输液导致症状减少,短暂的T淋巴细胞增加,机会性感染减少,病毒培养能力降低.
结论:
- 被动抗体输注是一种可行的策略,可以快速减少艾滋病毒病毒和抗原在晚期艾滋病.
- 这种方法可以赋予临时的被动免疫力,中和HIV,并通过减少机会性感染来改善临床结果.
- 对优化血量和供体选择的进一步研究可以增强被动抗体转移用于艾滋病毒/艾滋病管理的治疗潜力.
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