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Updated: Feb 21, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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溶酶体透通道TRPML3的冷电子显微镜结构

Marscha Hirschi1, Mark A Herzik2, Jinhong Wie3

  • 1Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, USA.

Nature
|October 12, 2017
PubMed
概括

TRPML3通道的结构揭示了粘脂蛋白域如何与酸-3,5-双酸盐 (PtdIns(3,5) P2结合,以激活 (Ca2+) 流动. 这一发现澄清了依赖脂质的TRPML通道封闭的机制.

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