定位11β-hydroxysteroid脱酶 - - 矿物质皮质类受体的组织特异性保护剂
C R Edwards1, P M Stewart, D Burt
1Department of Medicine, Western General Hospital, Edinburgh, UK.
Lancet (London, England)
|October 29, 1988
概括
在选择性组织中,矿物质皮质类固醇受体受到11β-类固醇脱酶 (11β-OHSD) 的保护. 这种酶是这种酶.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 生理学 生理学 生理学
背景情况:
- 矿物质皮质醇受体 (MR) 在体外表现出与阿尔多和皮质醇的非特异性结合.
- 在体内,尽管MR的非特异性,但对阿尔多的组织选择性存在.
- 这种选择性在脏和腺等组织中观察到,但在海马或心脏中没有.
研究的目的:
- 调查特定组织中阿尔多素选择性背后的机制.
- 确定11β-基类固醇脱酶 (11β-OHSD) 在调节MR活性中的作用.
- 解释11β-OHSD缺乏或抑制的生理后果.
主要方法:
- 在老鼠身上进行了实验.
- 在选择性和非选择性组织中测量了11β-OHSD的组织度.
- 进行了自身放射性研究,以评估酶抑制后的受体结合.
主要成果:
- 在阿尔多选择性组织中发现了11β-基类固醇脱酶 (11β-OHSD) 的较高度.
- 酶的局部化表明对皮质类固醇有偏或自的保护机制.
- 11β-OHSD的抑制导致保护的丧失,对皮质和阿尔多的结合部位类似.
结论:
- 11β-hydroxysteroid脱酶 (11β-OHSD) 通过代谢皮质类固醇,为特定的组织赋予阿尔多斯的选择性.
- 这种酶活性保护矿物质皮质类受体免受皮质类固醇的和.
- 这些发现解释了与11β-OHSD缺乏或甘露摄入相关的高血压和低血等疾病.
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