心肌梗塞幸存者患血管痴呆的风险较高
Jens Sundbøll1,2, Erzsébet Horváth-Puhó3, Kasper Adelborg3,2
1Department of Clinical Epidemiology (J.S., E.H.-P., K.A., M.S., L.P., V.W.H., H.T.S.) jens.sundboll@clin.au.dk.
Circulation
|October 14, 2017
概括
心肌梗塞 (MI) 幸存者面临血管痴呆的风险增加,特别是如果他们发生中风. 然而,心肌梗塞不会增加患阿尔茨海默病或其他痴呆症的风险.
科学领域:
- 心血管医学
- 神经学
- 流行病学
背景情况:
- 心肌梗塞 (MI) 幸存者可能因动脉样硬化和心肌梗塞后中风等共同风险因素而增加痴呆的风险.
- 为了了解长期的健康结果,研究心脏病发作后的痴呆风险至关重要.
研究的目的:
- 检查心肌梗塞 (MI) 和随后患痴呆症的风险之间的关系.
- 在心脏病发作后区分各种痴呆症 (阿尔茨海默病,血管痴呆症,其他痴呆症) 的风险.
主要方法:
- 一项基于1980-2012年丹麦医疗登记的全国性队列研究.
- 包括第一次心脏病发作患者和匹配的一般人群对照队列 (n=314,911 MI;n=1,573,193对照).
- 考克斯回归分析计算了超过35年的痴呆症调整风险比率 (aHR),同时控制了相关疾病和社会经济地位.
主要成果:
- 心肌梗塞 (MI) 与所有原因痴呆的风险增加无关 (aHR,1. 01).
- 患阿尔茨海默病 (aHR,0. 92) 和其他痴呆症的风险与一般人群相似.
- 心脏病发作与血管痴呆的风险显著增加 (aHR,1. 35),特别是在心脏病发作后发生中风的患者 (aHR,4. 48).
结论:
- 心肌梗塞 (MI) 与血管痴呆的风险增加有关,而后心肌梗塞的风险大大增加.
- 在有心脏病史的人群中,阿尔茨海默病和其他痴呆症的风险保持不变.
相关概念视频
Ischemic Heart Disease: Overview
3.6K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.6K
Imbalances in Cardiac Output
3.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.3K
Coronary Artery Disease I: Introduction
1.2K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.2K
Myocarditis III: Medical Management
238
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
238
Coronary Artery Disease III: Clinical Manifestations
445
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
445
Myocarditis I: Introduction
460
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
460


