在怀孕早期和经常性流产中,母亲对胎儿的免疫反应
I L Sargent1, T Wilkins, C W Redman
1Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford.
Lancet (London, England)
|November 12, 1988
概括
这项研究调查了反复发生的自发流产,发现了一些女性的细胞介导免疫变化. 然而,循环免疫因素与怀孕成功没有相关性,这挑战了现有的理论.
科学领域:
- 生殖免疫学 生殖免疫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 免疫遗传学 免疫遗传学
背景情况:
- 经常性自发流产 (RSA) 影响了许多女性,无法解释的病例带来了诊断挑战.
- 母亲对胎儿 (父) 抗原的免疫反应与RSA病原发生有关.
- 现有的理论表明,免疫排斥或缺乏免疫耐受性可能导致RSA.
研究的目的:
- 为了研究母亲细胞介导的免疫力对父亲的抗原在妇女有不明原因的反复性自发性流产.
- 评估细胞毒性抗体和血清阻断活性在RSA怀孕成功中的作用.
- 为了确定母体免疫反应的变化是否与重复的妊娠损失相关.
主要方法:
- 在怀孕前,怀孕初期和流产时,评估了母亲细胞介导的对父亲抗原的免疫力,在18名RSA女性和10名对照女性中进行了评估.
- 测量了母体细胞毒性全抗体的产生.
- 评估了母体血清对母体淋巴细胞激活的阻断作用.
主要成果:
- 在正常的早期怀孕或大多数RSA病例中没有观察到对父性抗原的一致的母细胞介导反应.
- 在三分之一的RSSA妇女中,在流产时检测到循环细胞毒性细胞.
- 在细胞毒性抗体产生,血清阻断活性和怀孕结果之间没有发现相关性.
结论:
- 细胞介导的免疫反应性可能会在一些经历反复自发流产的妇女中发生变化.
- 循环免疫阻断因素似乎与RSA.怀孕成功无关.
- 通过母体免疫接种与父白细胞预防RSA的机制仍然无法通过这些发现得到解释.
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