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Updated: Jun 18, 2026

Detection of Histone Modifications in Plant Leaves
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通过基因编码的活性位点相交联识别的HDAC8基质

Jeffrey E Lopez1, Sarah E Haynes1, Jaimeen D Majmudar1

  • 1Program in Chemical Biology, ‡Department of Chemistry, and §Department of Biological Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|October 17, 2017
PubMed
概括

通过一种新的化学交联方法确定了基因组脱酶8 (HDAC8) 基质. 这种方法克服了传统技术的局限性,使得能够无偏见地发现具有高催化效率的酶特异基质.

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相关概念视频

In-situ Hybridization02:31

In-situ Hybridization

In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...