干扰素α在与艾滋病相关的卡波西肉瘤中具有抗逆转录病毒作用
H C Lane1, J A Kovacs, J Feinberg
1Laboratory of Immunoregulation and Treatment Branch, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
Lancet (London, England)
|November 26, 1988
概括
复合干扰素-α (IFN-α) 在艾滋病和卡波西肉瘤患者中显示出抗瘤和抗逆转录病毒的益处. 用IFN-alpha治疗的早期阶段在CD4计数较高的患者中最有效.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 卡波西肉瘤是一种艾滋病定义的癌症.
- 人类免疫缺陷病毒 (HIV) 感染导致免疫抑制.
- 干扰素α (IFNα) 正在研究其在艾滋病毒/艾滋病治疗中的治疗潜力.
研究的目的:
- 评估复合干扰素-α (IFN-α) 的体内抗逆转录病毒活性.
- 评估艾滋病和卡波西肉瘤患者用IFN-alpha治疗的抗瘤反应.
主要方法:
- 进行了一项开放的治疗试验,其中21名患者被诊断患有艾滋病和卡波西肉瘤.
- 这些患者接受了复合干扰素α (IFN-α) 治疗.
- 监测了瘤反应和病毒载荷标记 (HIV p24),以及CD4+T细胞计数.
主要成果:
- 在21名患者中有8名 (38%) 观察到完全或部分抗瘤反应.
- 与未响应者 (154 细胞/μL) 相比,响应者具有显著更高的治疗前CD4计数 (399 细胞/μL).
- 具有较高CD4细胞计数 (>400细胞/μL) 的患者表现出显著的瘤减少,而具有较低CD4细胞计数 (<150细胞/μL) 的患者没有反应. 抗病毒作用,包括降低HIV p24水平和负HIV培养,在CD4计数较高的患者中最为明显.
结论:
- 复合干扰素-α (IFN-α) 在艾滋病毒和卡波西肉瘤患者中显示出抗瘤和抗逆转录病毒的益处.
- 用IFN-alpha治疗在HIV感染和卡波西肉瘤的早期阶段显得最有益,特别是在CD4+T细胞数量较高的患者中.
- IFN-alpha治疗可以显著降低病毒载量和瘤负担,表明其作为治疗选择的潜力.
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