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USP7小分子抑制剂干扰了无素的结合

Lorna Kategaya1,2, Paola Di Lello3, Lionel Rougé3

  • 1Department of Discovery Oncology, Genentech, South San Francisco, California 94080, USA.

Nature
|October 19, 2017
PubMed
概括

研究人员开发了选择性泛素特异性蛋白酶-7 (USP7) 抑制剂GNE-6640和GNE-6776,这些抑制剂将USP7从其催化位点远离. 通过诱导细胞死亡和增强药物细胞毒性,这些抑制剂在癌症治疗中具有前景.

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