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相关概念视频

Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...

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相关实验视频

Updated: Jun 11, 2026

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
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在老鼠神经发育过程中进行多尺度的3D基因组重新连接

Boyan Bonev1, Netta Mendelson Cohen2, Quentin Szabo1

  • 1Institute of Human Genetics, UMR 9002 of the CNRS and the Université de Montpellier, 34396 Montpellier, France.

Cell
|October 21, 2017
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概括

这项研究绘制了神经发育过程中的基因组折叠图,揭示了3D染色体组织如何影响基因表达和细胞命运. 关键的发现是转录与染色体隔离以及在分化过程中的动态相互作用.

关键词:
三维基因组架构这里是H-C聚合器皮层的发展增强剂神经分化转录转录因子

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Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
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相关实验视频

Last Updated: Jun 11, 2026

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09:25

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Published on: June 4, 2014

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科学领域:

  • 基因组学
  • 发育生物学
  • 表观遗传学

背景情况:

  • 染色体构造捕获 (3C) 技术为基因组折叠提供了洞察力.
  • 3D基因组架构,基因表达和细胞命运之间的关系尚未完全理解.

研究的目的:

  • 在小鼠神经分化过程中全面绘制3D染色体组织.
  • 研究基因表达和细胞命运决定的基因组折叠的动态.

主要方法:

  • 产生高分辨率的高C地图.
  • 在体外和体内神经分化的染色体组织分析.
  • 对Polycomb网络动态和转录因子相互作用的研究.

主要成果:

  • 转录与染色质隔离和长距离相互作用相关.
  • 通过dCas9的激活不会产生新的TAD边界.
  • 跨细胞类型的活跃基因体之间存在长距离接触.
  • 在神经分化过程中,活跃的TAD接触减少,而非活跃的TAD接触增加.
  • 聚合物网络解体, 神经转录因子相互作用出现.
  • 细胞类型特定的增强剂-促进剂与基因表达形成接触.

结论:

  • 在神经发育过程中,多种因素会动态地影响色素相互作用.
  • 三维基因组组织在调节基因表达和细胞命运方面发挥着至关重要的作用.
  • 发育过渡包括显著的染色体结构重塑.