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的高效和快速机械化学组装

Amine Garci¹, Katherine J Castor¹, Johans Fakhoury¹

¹Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montréal, Québec H3A 0B8, Canada.

Journal of the American Chemical Society

|October 24, 2017

概括

在几分钟内迅速合成的超分子方形. 这些复合物表现出对瓜四重复合物,特别是端粒RNA (TERRA) 序列的亚微分子结合性.

科学领域:

超分子化学
机械化学
协调化学

背景情况:

超分子方形复合物在各种应用中具有价值.
传统的基于溶液的合成方法耗时且产量有限.
复杂的组装需要新的,高效的合成路径.

研究的目的:

开发一种快速有效的合成超分子复合物的方法.
研究机械化学和基于溶液的合成之间的机制差异.
评估这些复合物的与生物相关的关四重复合物的结合.

主要方法:

一个,两步合成的球磨机械化学.
从K2PtCl4中合成[Pt4NN]4][CF3SO3]8方位.
光位移测定 (FID) 和异热定位热量计 (ITC) 用于结合性研究.

主要成果:

在几分钟内成功合成超分子方形,
机械化学合成避免了慢溶液方法中出现的寡合子副产品.
观察到对关氨酸四重体的亚微分子结合亲缘关系,偏好对端粒RNA (TERRA).

结论:

与溶液方法相比,球磨提供了更快,更有效的超分子方形的途径.
合成的金属方块对TERRA具有强烈的选择性结合.
这些发现为开发针对DNA和RNA结构的基于的新疗法开辟了道路.

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