在尾部大脑干中控制机速的电路
Paolo Capelli1,2, Chiara Pivetta1,2, Maria Soledad Esposito1,2
1Biozentrum, Department of Cell Biology, University of Basel, 4056 Basel, Switzerland.
Nature
|October 24, 2017
概括
研究人员在小鼠脑干中发现了多种不同类型的神经元, 侧向巨细胞核 (LPGi) 中的质神经元对于高速运动至关重要.
科学领域:
- 神经科学
- 发动机控制
- 行为生物学
背景情况:
- 动作对于动物的生存和运动至关重要.
- 找出控制运动的特定神经元是一项挑战.
- 尾部大脑干在运动中的作用需要进一步阐明.
研究的目的:
- 在尾部大脑干中识别和描述调节运动的神经元子群.
- 了解不同类型神经元 (谷氨基,糖能) 在运动控制中的特定作用.
- 研究这些神经元与更高的运动中心和脊髓电路的连接.
主要方法:
- 使用电微刺激的经典实验.
- 基于位置,神经递质身份和连接性研究的神经元子群.
- 检查从尾部大脑干到脊髓效应电路的下降路径.
主要成果:
- 在小鼠尾部大脑干中发现了功能异质的神经元子群,影响运动.
- 侧向巨细胞核 (LPGi) 中的质神经元对于高速运动至关重要.
- 甘氨酸抑制神经元诱导行为停止,具有明显的尾部脑干映射.
- 在LPGi亚群中显示出明显的脊髓预测.
结论:
- 尾部大脑干包含多样化,混合的神经元子群,在运动中具有相反的作用.
- 特定的大脑干神经元群对于执行运动程序和调节运动参数至关重要.
- 发现神经元的多样性解决了关于大脑干控制运动的历史争议.
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