自组装的水溶性纳米纤维显示原混合
Boi Hoa San1, Jeongmin Hwang1, Sujatha Sampath1
1Department of Bioengineering, University of Utah , Salt Lake City, Utah 84112, United States.
Journal of the American Chemical Society
|November 2, 2017
概括
原混合化 (CHP) 自组合成纳米纤维,以向组织中的失质原 (dColl). 这些纳米纤维为疾病检测和向药物输送提供了多功能平台.
科学领域:
- 生物材料科学
- 纳米技术
- 分子生物学
背景情况:
- 原混合 (CHP) 有效地向患病或受伤的组织中的原 (dColl).
- 的自组合成纳米结构是生物材料开发的关键策略.
研究的目的:
- 开发和特征自组装纳米纤维从CHP与β-sheet图案结合.
- 评估这些新型纳米纤维的结合亲和力,准能力和潜在应用.
主要方法:
- 将β片基因组合到CHP以诱导自组合成纳米纤维.
- 纳米纤维结构,可溶性和聚合性质的表征.
- 在小鼠体外和体内测试以评估结合dColl和组织向性.
主要成果:
- 基于CHP的纳米纤维具有精确的结构,高水溶性,没有聚合.
- 在未经预激活的情况下,纳米纤维在体外和体内表现出高亲和力结合dColl.
- 可调节的纳米纤维长度 (从100nm到微米) 允许在静脉注射后对dColl在骨组织中的特定向.
结论:
- 电加热纳米纤维是检测和捕获dColl的一个有前途的工具.
- 这些纳米纤维可以帮助理解疾病中的细胞外矩阵重塑.
- 开发的纳米纤维代表了针对原相关疾病的新型传递系统.
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