普莱克辛-B2调解血管新生素的生理和病理功能
Wenhao Yu1, Kevin A Goncalves2, Shuping Li1
1Molecular Oncology Research Institute, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA; Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Cell
|November 4, 2017
概括
素B2 (PLXNB2) 作为细胞表面受体对血管新生素 (ANG) 起作用,调解其在细胞生长和再生中的作用. 针对这种相互作用显示出对癌症和神经退行性疾病的治疗潜力.
科学领域:
- 生物化学
- 细胞生物学
- 分子医学
背景情况:
- 血管新生素 (ANG) 是一种参与细胞生长,存活和再生的核糖酶 (RNase).
- 它的功能需要受体介导的内细胞分裂,但其细胞表面受体以前未被确定.
研究的目的:
- 识别功能性细胞表面受体的血管新生素 (ANG).
- 研究该受体在ANG介导的细胞过程中的作用.
- 评估针对ANG受体相互作用的治疗潜力.
主要方法:
- 使用各种细胞类型 (内皮细胞,癌细胞,神经细胞,造血干细胞和前代细胞) 的功能测试.
- 鉴定Plexin-B2 (PLXNB2) 作为ANG受体
- 在实验室和体内使用抗体对抗PLXNB2的ANG结合部位的研究.
主要成果:
- 在多种细胞类型中,Plexin-B2 (PLXNB2) 被确定为ANG的功能受体.
- PLXNB2调解细胞内RNA处理,有助于ANG对细胞生长,存活和再生的影响.
- 针对PLXNB2- ANG相互作用的抗体抑制了瘤生长,促进了神经保护,并减少了白血病的进展.
结论:
- PLXNB2对于ANG的生理和病理功能都是必不可少的.
- 针对PLXNB2-ANG相互作用为固体和造血性癌症提供治疗前景.
- 对于神经退行性疾病来说,PLXNB2-ANG途径是一个潜在的治疗点.
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