为协调大脑状态调节的祖先电路
Matthew Lovett-Barron1, Aaron S Andalman1, William E Allen2
1Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; CNC Program, Stanford University, Stanford, CA 94305, USA.
Cell
|November 7, 2017
概括
研究人员发现了多种神经调节细胞类型,包括单氨基,胆氨基和氨基神经元,它们调节大脑的警觉性. 这些发现揭示了斑马鱼和小鼠内部状态的进化保护机制.
科学领域:
- 神经科学
- 行为生物学
- 基因组学
背景情况:
- 大脑的内部状态对行为有很大影响.
- 神经调节控制着像警觉这样的波动状态, 但潜在的机制和细胞类型仍然不清楚.
研究的目的:
- 开发一种用于全球选涉及行为细胞类型的方法.
- 确定控制警觉性的特定神经调节细胞类型.
- 研究这些细胞类型及其功能的进化保存.
主要方法:
- 开发了MultiMAP:一种整合大脑活动成像,分子表型和细胞分辨率体积记录的方法.
- 在反应时间任务中记录了22种神经调节细胞类型的行为.
- 从小鼠的同类神经调节细胞中记录和控制.
主要成果:
- 确定了与斑马鱼警觉相关的多种单氨基,胆氨基和氨基细胞类型.
- 发现这些细胞类型在高度警觉时有相互相关的活动.
- 在小鼠中展示了与警觉相关的细胞类型动态和行为调节的惊人进化保护.
结论:
- 建立了MultiMAP作为一种不偏见的发现细胞的基本行为.
- 揭示了一组不同的神经调节系统共同控制大脑内部状态.
- 突出了神经调节在行为调节和内部状态控制中的重要性.
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