尿素分泌作为生活在非常性环境中的鱼类生存策略
D J Randall1, C M Wood, S F Perry
1Department of Animal Physiology, Veterinary College, University of Nairobi, Kenya.
Nature
|January 12, 1989
概括
在肯尼亚性马加迪湖的鱼排泄尿素,与大多数淡水鱼不同. 这种尿素的生产,通过鸟-尿素循环,使他们能够在极端的pH条件下生存.
科学领域:
- 比较生理学比较生理学
- 生物化学 生物化学
- 环境适应环境适应
背景情况:
- 氨的分泌在淡水鱼中很常见,但有毒.
- 尿素的生产是代谢上昂贵的,通常在陆地脊椎动物或海洋鱼类中发现.
- 甲素-尿素循环通常在淡水teleosts中被抑制.
研究的目的:
- 研究居住在高性马加迪湖的鱼中分泌的机制.
- 为了确定甲素-尿素循环是否在生存于极端pH的鱼中活跃.
- 了解使在性环境中生存的生理适应.
主要方法:
- 在马加迪湖的鱼中分析废物 (氨,尿素).
- 在鱼肝脏中检测甲素-尿素循环成分的酶测定.
- 与缺乏这些酶的相关淡水鱼类物种进行比较.
- 相关物种对马加迪湖水的实验暴露.
主要成果:
- 来自马加迪湖的鱼 (Oreochromis alcalicus grahami) 完全排泄尿素.
- 这些鱼在肝脏中具有活跃的甲素-尿素循环酶.
- 一种相关的淡水物种缺乏这些酶,并分泌氨.
- 相关物种在马加迪湖的性水中迅速死亡.
结论:
- 通过花素-尿素循环的尿素生产对于在马加迪湖极端性环境下鱼的生存至关重要.
- 这种适应使Oreochromis alcalicus grahami能够在对相关物种致命的环境中壮成长.
- 该研究强调了特定代谢途径在使脊椎动物适应极端环境中的作用.
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