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细胞神经元信号的基因变异调节了衰老的速度

Jiang-An Yin¹, Ge Gao^1,2, Xi-Juan Liu¹

¹Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.

|November 10, 2017

概括

研究人员发现C. 特定的基因RGBA-1和NPR-28影响交配行为的下降,

科学领域:

遗传学
神经科学
老龄化研究

背景情况:

在老化过程中,行为衰退的速度在个体之间有很大差异.
确定控制健康衰老的因素至关重要,
衰老速度的自然变化为我们提供了深入了解底层的生物机制.

研究的目的:

研究Caenorhabditis elegans老化速度的自然变化的遗传基础.
识别特定的基因和信号通路, 调节与年龄相关的行为衰退的速度.
了解细胞神经元在调节衰老过程中的作用.

主要方法:

对C. elegans分离物的比较分析,以评估寿命的变化和与年龄相关的行为衰退 (雄性,喉抽,运动).
基因分析以识别基因中的DNA多态,包括一种新的编码基因 (rgba-1) 和一种神经受体基因 (npr-28).
功能性研究以确定RGBA-1和NPR-28信号如何影响与年龄相关的交配行为下降及其与线粒体通路的联系.

主要成果:

单独的C. elegans表现出不同的寿命和与年龄相关的各种行为下降率.
调节行为衰老基因-1 (rgba-1) 和npr-28基因中的DNA多态性显著影响交配行为的下降速度.
在神经元中激活NPR-28信号,通过SIR-2.1和线粒体展开的蛋白质反应加速行为衰老.

结论:

神经介导的质神经元信号的自然变化是C. elegans中衰老速度的关键调节者.
涉及神经元信号和线粒体反应的RGBA-1/NPR-28通路提供了一种影响行为衰老的新机制.
这些发现突显了对衰老变异性的遗传控制,并提出了促进健康衰老的潜在目标.

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