Lysophosphatidylcholine 在人类疟疾寄生虫Plasmodium falciparum中调节性阶段的分化

Nicolas M B Brancucci ¹, Joseph P Gerdt ², ChengQi Wang ³

¹Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK; Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02155, USA.
²Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology, Boston, MA 02155, USA.
³Center for Global Health & Infectious Diseases Research, Department of Global Health, College of Public Health, University of South Florida, Tampa, FL 33620, USA.
⁴Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK; Centre for Immunity, Infection and Evolution, Institute for Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3FL, UK.
⁵Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland; University of Basel, 4001 Basel, Switzerland.
⁶Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
⁷Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02155, USA.
⁸Department of Pharmaceutical and Organic Chemistry, Faculty of Pharmacy, University of Granada, 18010 Granada, Spain.
⁹Institute of Technical Biochemistry, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-924 Lodz, Poland.

⁰Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK; Harvard T.H. Chan School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02155, USA.

疟疾寄生虫感知宿主酸胆 (LysoPC) 来控制性差异化. 限制LysoPC会触发游戏细胞的产生,从而提供新的疟疾传播阻断策略.

科学领域

疟疾寄生虫生物学
细胞分化
宿主-病原体相互作用

背景情况

疟疾寄生虫的传播是一个瓶,也是根除的目标.
对寄生虫感染蚊媒的性差异化至关重要.
影响子细胞生产的环境因素尚未完全理解.

研究的目的

研究宿主衍生信号在Plasmodium falciparum性分化的作用.
识别特定的宿主分子控制游戏细胞的产生.

主要方法

用 lysophosphatidylcholine (LysoPC) 治疗Plasmodium falciparum培养物
脂质生物合成途径的分析.
评估性阶段特异性的转录和雌激细胞形成.

主要成果

宿主衍生的酸胆 (LysoPC) 抑制了Plasmodium的性分化.
外源性LysoPC可促进酸丁胆的生物合成.
限制LysoPC激活了寄生虫的新陈代谢,导致了雌性细胞的产生.

结论

寄生虫可以感知并响应像LysoPC这样的宿主生理信号来调节细胞命运.
作为疟疾寄生虫性分化的关键调节剂.
了解这种途径为阻止疟疾传播提供了新的目标.

关键词:

肯尼迪路径虫环境传感化酸胆疟疾脂代谢性差异化传输方式

Lysophosphatidylcholine 在人类疟疾寄生虫Plasmodium falciparum中调节性阶段的分化

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科学领域

背景情况

研究的目的

主要方法

主要成果

结论

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Lysophosphatidylcholine 在人类疟疾寄生虫Plasmodium falciparum中调节性阶段的分化

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概括

科学领域

背景情况

研究的目的

主要方法

主要成果

结论

关键词:

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