在家族性高胆固醇血症中发展冠心病
H Mabuchi1, J Koizumi, M Shimizu
1Department of Internal Medicine, Kanazawa University School of Medicine, Japan.
Circulation
|February 1, 1989
概括
家族性高胆固醇血症患者在早期发展出冠状动脉疾病. 心肌梗塞发生在30多岁的男性和40多岁的女性中,异性卵子中发生过早死亡.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 家族性高胆固醇血症 (FH) 是一种遗传性疾病,导致高的LDL胆固醇.
- FH显著增加了早发心血管疾病的风险.
- 了解FH的疾病进展对于及时干预至关重要.
研究的目的:
- 研究家族性高胆固醇血症患者冠状动脉疾病 (CAD) 的发展和进展.
- 为了确定在异合体和同合体FH患者中CAD的发病年龄和严重程度.
- 建立基于年龄的冠状动脉狭窄的回归模型.
主要方法:
- 对10名同卵性和692名异卵性FH患者的回顾性分析.
- 在一小部分患者中进行冠状动脉血管学评估.
- 统计分析以确定年龄和冠状动脉狭窄指数之间的回归方程.
主要成果:
- 心肌梗塞 (MI) 影响了22%的男性和10%的女性异构卵子,分别从第3和第4十年开始.
- 冠心病 (CHD) 导致70%的已故异合体患者死亡,男性 (54岁) 的平均死亡年龄明显低于女性 (69岁).
- 回归分析预测了17岁后在男性中和25岁后在女性中与异性FH进行血管学检测的冠状动脉狭窄.
结论:
- 冠状动脉疾病在患有家族性高胆固醇血症的患者中早期发展,特别是在男性中.
- 在异合性FH患者的脂质降低疗法可能会推迟到青春期晚期,基于预测的狭窄发作.
- 早期识别和管理策略对于减轻FH心血管风险至关重要.
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