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Updated: Feb 18, 2026

In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
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通过Shigella效应物抑制宿主防御的GBPs的化和降解

Peng Li1,2, Wei Jiang2, Qin Yu2

  • 1Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, National Institute of Biological Sciences, Beijing, 102206, China.

Nature
|November 17, 2017
PubMed
概括

通过使用IpaH9.8效应器降解酸结合蛋白 (GBPs),Shigella flexneri细菌逃避免疫防御. 破坏这一过程使GBPs能够抑制细菌生长,揭示了宿主-病原体相互作用的关键机制.

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