长期的压力会改变体循环的动态,导致决策不当
Alexander Friedman1, Daigo Homma1, Bernard Bloem1
1McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell
|November 18, 2017
概括
慢性压力会影响决策, 这涉及到前额叶皮质 - 状回路活动的改变,可能是决策异常的潜在障碍.
科学领域:
- 神经科学
- 行为科学
- 决策科学
背景情况:
- 有效的成本效益评估对于合理的决策至关重要.
- 在神经精神疾病和慢性压力后, 这种能力受到损害,
研究的目的:
- 研究慢性压力如何影响动物的成本效益评估和决策.
- 探索这些行为变化背后的前额状回路中的神经机制.
主要方法:
- 动物受到长期的压力.
- 行为任务评估成本效益评估和决策.
- 电生理学记录了中部前额叶皮层和条纹体中的神经活动.
- 视觉遗传学被用来操纵电路活动.
主要成果:
- 慢性压力导致非最佳决策,其特点是增加了高成本/高回报的选择.
- 压力改变了中部前额叶皮质和其条状点的神经元活动.
- 观察到纹状投射神经元和快速发射神经元的变化,表明激发抑制平衡发生了改变.
结论:
- 基于体的电路中的激发抑制动态变化可能是压力诱导的异常决策的基础.
- 前额状电路功能障碍是慢性压力与冲突下决策障碍相关的潜在机制.
相关概念视频
Stress and Mental Health
974
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
974
Psychological Responses to Stress
749
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
749
Hypothalamic-Pituitary Axis
66.8K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.8K
Psychoneuroimmunology: Cardiovascular Disease
591
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
591
Physiological Foundation of Stress
736
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
736
Psychoneuroimmunology: Diabetes and Cancer
517
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
517


