风险业务:影响压力决定的循环
Amy F T Arnsten1, Daeyeol Lee2, Christopher Pittenger3
1Departments of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; Child Study Center, Yale University School of Medicine, New Haven, CT 06510, USA.
Cell
|November 18, 2017
概括
压力会破坏前额叶皮层对条状回路的控制, 这种机制可以解释与压力相关的药物滥用和自动行为的抑制.
科学领域:
- 神经科学
- 行为科学
背景情况:
- 众所周知,压力会影响决策.
- 了解压力引起的行为变化背后的神经机制至关重要.
研究的目的:
- 研究压力如何影响神经电路层面的决策.
- 阐明前额皮层与状皮层在与压力相关的行为中的作用.
主要方法:
- 这项研究使用动物模型来检查神经电路活动.
- 研究了前额叶皮层在压力下对条状回路的抑制控制.
主要成果:
- 发现压力会破坏前额叶皮层在条状回路上的抑制功能.
- 这种干扰导致动物对潜在的负面后果或损失变得不敏感.
- 结果表明有直接的神经通路, 通过这种通路, 压力会促使人们做出危险的决定.
结论:
- 压力会通过改变前额叶皮质-状皮质通路的功能来削弱执行控制.
- 这种神经失调可能是与压力相关的疾病,
- 这种机制也可以解释自动行为失禁,
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