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PP1:Tautomycetin复合揭示了开发PP1特异性抑制剂的途径

Meng S Choy1, Mark Swingle2, Brandon D'Arcy2

  • 1Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.

Journal of the American Chemical Society
|November 21, 2017
PubMed
概括

陶托米塞丁 (TTN) 是一种高度选择性的蛋白质酸酶1 (PP1/PPP1C) 抑制剂. 这种选择性源于与PP1特异性半氨酸残留物的共价键,使得新的研究工具成为可能.

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