用卵巢刺激进行子宫内授精与未解释不育症 (TUI) 的预期治疗:实用性,开放性,随机化,受控的两中心试验
Cynthia M Farquhar1, Emily Liu2, Sarah Armstrong1
1Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand; Fertility Plus, Auckland District Health Board, Auckland, New Zealand.
Lancet (London, England)
|November 28, 2017
概括
与预期孕妇相比,卵巢刺激的宫内受精 (IUI) 显著提高了无法解释的不孕症妇女的活产率. 这种有效的生育治疗为预后不佳的女性提供更高的怀孕机会.
科学领域:
- 生殖医学
- 临床试验
- 治疗不孕症
背景情况:
- 无法解释的不孕症影响了许多女性,宫内授精 (IUI) 和卵巢刺激经常被作为体外受精 (IVF) 的替代品.
- 有限的证据支持IUI在无法解释的不孕症中的有效性.
- 由于证据不足,英国的指导方针建议不定期为不明原因的不孕症提供IUI.
研究的目的:
- 评估卵巢刺激IUI的有效性和安全性与未解释的不孕症和不良预后的妇女的预产管理.
- 确定累计活产率作为主要结果.
主要方法:
- 一个实用的,开放的,随机的受控试验,涉及不明原因的不孕症和自然受孕预后不佳的妇女.
- 参与者被分配到三个周期的卵巢刺激 (使用克洛米芬酸盐或莱特) 或三个周期的预期管理.
- 主要结论是预期治疗人群中累计的活产率.
主要成果:
- 与预产期治疗相比,接受卵巢刺激的女性的累积活产率显著提高 (31% vs 9%).
- 在IUI组中,活产的风险比为3. 41 (95% CI为1. 71- 6. 79; p=0.0003).
- 大多数IUI组的活产是治疗的结果,而预期管理组包括一些非协议怀孕.
结论:
- 通过卵巢刺激进行子宫内受精是一种安全有效的治疗方法,用于预后不佳的女性.
- 这项研究提供了强有力的证据支持在该患者群体中使用IUI与卵巢刺激.
- 这种方法提供了可行的生育治疗选择,提高了受孕率.
更多相关视频
05:31OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
Published on: May 9, 2021
4.8K
08:06Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality
Published on: October 18, 2024
906
相关概念视频
01:24In Vitro Fertilization
1.1K
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
1.1K
01:23Infertility in Males
587
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
587
01:21Intrauterine Drug Delivery Systems
23
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
23