长期行为模式和个性的神经调节控制
Shay Stern1, Christoph Kirst2, Cornelia I Bargmann3
1Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, NY 10065, USA.
Cell
|December 5, 2017
概括
这项研究表明,虽然发育程序塑造了虫的行为,但个体虫表现出独特的非遗传偏见. 神经调节器精确调整这些行为轨迹和个性.
科学领域:
- 神经科学
- 发育生物学
- 行为遗传学
背景情况:
- 动物的行为是由发展计划和个体变化所塑造的.
- 了解这些因素之间的相互作用对于理解行为复杂性至关重要.
研究的目的:
- 调查发育计划和个体变异对Caenorhabditis elegans行为的贡献.
- 确定影响行为轨迹和个性的分子机制和神经调节系统.
主要方法:
- 在整个发育过程中监测单独的Caenorhabditis elegans线虫.
- 在高时空分辨率下量化自发的食行为.
- 分析特定神经调节剂 (多巴胺,血清素,NPR-1,DAF-7) 对行为模式的影响.
主要成果:
- 在不同发育阶段观察到可复制和刻板印象的自发食行为.
- 像多巴胺和血清激素这样的神经调节剂对行为轨迹表现出特定阶段的影响.
- 一组个体表现出一致的非遗传性行为偏见,独立于他们的同位素背景.
- 发现神经调节系统可以调节非遗传个性的程度.
结论:
- 在C. elegans的行为发展受到神经调节器影响的模块化时间程序的控制.
- 非遗传的个体变异在塑造持续的行为模式中起着重要作用.
- 神经调节可以动态调节发育和个人的行为组成部分.
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