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非心脏手术后的心肌损伤:发生率,死亡率和特征
Christian Puelacher1, Giovanna Lurati Buse2, Daniela Seeberger3
1Department of Cardiology and Cardiovascular Research Institute Basel (C.P., D.S., L.S., S.M., J.E., I.S., K.W., R.T., J.d.F.d.L., S.O., C.M.) christian.mueller@usb.ch.
Circulation
|December 6, 2017
概括
在非心脏手术后,外科手术期间心肌损伤 (PMI) 是常见的,通常没有查. 通过托洛T查的早期检测显示PMI显著增加死亡风险.
科学领域:
- 心脏病学
- 心血管外科
- 内部医学
背景情况:
- 术后心肌损伤 (PMI) 是非心脏手术后死亡的一个已知的因素.
- 大多数PMI病例无症状,导致没有系统查方案的诊断不足.
研究的目的:
- 在接受非心脏手术的患者中调查术后心肌损伤 (PMI) 的发生率和结果.
- 将PMI患者与非PMI患者之间的死亡率进行比较,并评估急性心肌梗塞诊断标准对结果的影响.
主要方法:
- 一项前性诊断研究,涉及连续接受非心脏手术的心血管风险增加的患者.
- 使用连续的高灵敏性心脏素T测量进行系统的PMI查.
- 从手术前到手术后的测量中,PMI 的绝对增加是≥14 ng/L.
主要成果:
- 在2546例手术中,PMI发生在16%,原始30天死亡率为8. 9%,而没有PMI的患者为1. 5% (P<0. 001).
- 在PMI患者中,调整后的30天死亡率为2. 7 (95% CI,1. 5- 4. 8),差异在1年内持续存在.
- 在符合或不符合自发性急性心肌梗塞的PMI患者中,死亡率在30天内是可比的 (10. 4%对比8. 7%,P=0. 684).
结论:
- PMI是非心脏手术的常见并发症,与显著的短期和长期死亡率有关.
- 常规的临床查有效地检测PMI,突出其临床重要性.
- 无论是否满足自发性急性心肌梗塞的额外标准,与PMI相关的死亡率似乎是相似的.
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