在非淋巴细胞组织和瘤中Runx3程序CD8+T细胞的存在
J Justin Milner1, Clara Toma1, Bingfei Yu1
1Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Nature
|December 7, 2017
概括
转录因子Runx3对于组织内存CD8+T细胞 (TRM) 的发展和持续至关重要. Runx3还影响瘤中的T细胞存在,影响癌症免疫治疗结果.
科学领域:
- 免疫学
- 细胞生物学
- 分子生物学
背景情况:
- 组织内存CD8+T细胞 (TRM) 对于病原体进入部位的快速免疫反应至关重要.
- 控制TRM细胞分化和维持的分子机制仍然不完全理解.
研究的目的:
- 确定控制TRM细胞分化和稳态的关键分子调节剂.
- 研究Runx3在TRM细胞功能中的作用及其对癌症免疫力的影响.
主要方法:
- 对TRM前体细胞与循环记忆前体细胞的基因表达和染色质可访问性的比较分析.
- 计算和体内RNA干扰查以确定调节因素.
- 在TRM细胞分化和黑色素瘤采用T细胞治疗的小鼠模型中评估Runx3功能.
主要成果:
- 与循环记忆前体相比,TRM前体细胞具有不同的分子形状.
- 转录因子Runx3被确定为TRM细胞分化和组织存在的关键调节者.
- Runx3 缺乏会损害组织中的TRM细胞积累和抗瘤免疫力,而其过度表达会增强这些过程.
- 在TRM细胞和瘤透性淋巴细胞中观察到与Runx3活性相关的共同核心基因表达特征.
结论:
- 在各种组织中,Runx3是建立和维护TRM细胞群的必不可少的中央调节剂.
- Runx3活性与瘤中的T细胞存在有关,这表明它有可能成为改善癌症免疫治疗的标.
- 了解Runx3的作用可以为提高疫苗疗效和采用T细胞疗法的策略提供信息.
相关概念视频
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.