对于先天性心脏病的干细胞治疗:一个系统的审查
Diamantis I Tsilimigras1,2, Evangelos K Oikonomou3, Demetrios Moris2,4
1School of Medicine (D.I.T.).
Circulation
|December 13, 2017
概括
干细胞疗法对先天性心脏病 (CHD) 治疗具有前景,可能与手术一起改善心脏功能和生活质量. 为了在精心设计的临床试验中确认疗效和安全性,进一步的研究至关重要.
科学领域:
- 复原医学
- 心脏病学
- 生物技术
背景情况:
- 遗传性心脏病 (CHD) 是一种常见且多样化的出生缺陷.
- 虽然手术是标准的,但干细胞治疗正在成为特定类型的冠状动脉疾病的补充或替代治疗方法.
- 本研究回顾了有关心脏病干细胞治疗的现有证据和研究.
研究的目的:
- 对先天性心脏病 (CHD) 基于干细胞的治疗策略进行系统审查.
主要方法:
- 进行了Medline,ClinicalTrials.gov和Cochrane图书馆的系统审查.
- 搜索包括截至2017年4月23日的研究及其参考列表.
主要成果:
- 审查了19项研究:8项临床前,6项临床和5项正在进行的试验.
- 报道了各种干细胞输送途径 (冠心内,心内,静脉内,心上).
- 临床前研究通常以右心室功能障碍和肺高血压为模型;临床试验主要集中在左心脏缺血综合征上.
- 基于细胞的组织工程用于自我生长的移植和补丁是最近的发展.
结论:
- 干细胞输送可能比单独手术治疗心脏病有好处,改善心脏功能,生长和生活质量.
- 鼓舞人心的初步结果需要精心设计的临床试验来证实疗效和安全性.
- 进一步的实验室研究和转化为大型临床研究对于这种潜在的突破性方法至关重要.
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