对于绝经后妇女慢性疾病的初级预防,荷尔蒙疗法:美国预防服务工作组建议声明
, David C Grossman1, Susan J Curry2
1Kaiser Permanente Washington Health Research Institute, Seattle.
JAMA
|December 14, 2017
概括
绝经期的激素治疗提供了有限的益处,但在预防慢性疾病方面存在风险. 美国预防服务工作组建议绝大多数绝经后妇女不使用.
科学领域:
- 预防医学
- 女性健康
- 内分泌学
背景情况:
- 发生在51岁左右的更年期与慢性疾病风险增加有关.
- 由于安全问题,更年期后激素治疗的使用量有所下降.
研究的目的:
- 更新关于预防慢性疾病的更年期激素治疗的建议.
- 评估绝经后妇女的全身激素治疗的益处和危害.
主要方法:
- 对用于慢性疾病的初级预防的激素治疗的证据进行系统审查.
- 对益处,危害和子组变化的分析.
主要成果:
- 荷尔蒙疗法显示了小到中等的益处和危害.
- 对于有子宫的女性来说,结合雌激素和孕激素没有净益处.
- 对于没有子宫的女性来说,雌激素本身并没有任何好处.
结论:
- 美国预防服务工作组建议不要使用雌激素和孕激素联合治疗.
- 美国预防服务特别工作组建议女性切除子宫后不要单独使用雌激素治疗.
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