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Updated: Feb 17, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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TMEM16A活性化化通道的冷EM结构

Shangyu Dang1, Shengjie Feng2, Jason Tien2

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA.

Nature
|December 14, 2017
PubMed
概括

这项研究介绍了TMEM16A活性化化通道 (CaCC) 的新原子结构,揭示了其离子透孔和功能状态. 这些发现确定了控制阴离子导电和通道封闭的关键残留物,这对于理解CaCC的生理作用至关重要.

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