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通过RHEB激活mTORC1和通过PRAS40抑制的机制

Haijuan Yang1, Xiaolu Jiang1,2, Buren Li1

  • 1Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

Nature
|December 14, 2017
PubMed
概括

拉巴胺素复合物1 (mTORC1) 结构的机理性标揭示了RHEB结合如何激活激酶以及癌症突变如何模仿这种激活. 这些见解解释了mTORC1基质的选择和调节.

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