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Giuliana Fusco1,2, Serene W Chen1,2, Philip T F Williamson3

  • 1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.

Science (New York, N.Y.)
|December 16, 2017
PubMed
概括

在帕金森病中,有毒的α-synuclein小分子会破坏神经元功能. 研究人员确定了使这些寡合物能够损害细胞膜的关键结构特征,

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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