在孤立的左捆分支块中的功能异常. 腹腔间异步效应的影响
C L Grines1, T M Bashore, H Boudoulas
1Department of Internal Medicine, Ohio State University, Columbus.
Circulation
|April 1, 1989
概括
左捆支部阻塞 (LBBB) 导致左心室功能的显著延迟,影响透缩时间和心声振幅. 这导致LBBB患者的隔膜贡献减少和整体排泄分数减少.
科学领域:
- 心脏病学 心脏病学
- 心脏电生理学 心脏电生理学
- 心血管成像 - 心血管成像
背景情况:
- 左捆支部阻塞 (LBBB) 是一种心脏导电异常,影响心室激活序列.
- 了解LBBB在心室力学和血液动力学上的功能影响对于患者管理至关重要.
研究的目的:
- 为了研究孤立的左束分支块 (LBBB) 对左心室和右心室功能和时间的影响.
- 将LBBB患者的心脏机械事件与正常人进行比较.
主要方法:
- 采用多模式方法,包括心顶图,心声图,心电图,心声图 (2D和双M模式) 和放射性核酸心室图 (RNV).
- 将18名患有孤立LBBB的患者与10名正常对照患者进行了比较.
主要成果:
- LBBB显示左心室内缩和透缩事件的显著延迟,缩短透缩并增加右至左心室透缩时间比.
- 在LBBB中观察到第一个心声 (S1) 幅度 (S1/S2比) 的降低,这归因于膜贡献者的分离扩大.
- 在LBBB中异常的腹腔间隔膜运动反映了异步的腹腔收缩和喷射.
- 与对照组相比,RNV显示LBBB患者的隔膜区域喷射率降低和全球喷射率降低.
结论:
- 孤立的LBBB破坏了正常的腹腔间同步,导致左心室功能受损.
- 该研究突出显示,在LBBB.中,透析时间,心声特征和区域/全球射出分数的显著变化.
- 这些发现强调了LBBB对整体心脏表现的机械影响.
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