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CD19 CAR T 细胞
1Center for Cell Engineering, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.
Cell
|December 16, 2017
概括
化学抗原受体 (CARs) 重新编程免疫细胞以向瘤. 自主 CAR T 细胞由患者血液生成并扩展以消除癌细胞,提供治疗方法.
科学领域:
- 免疫学
- 生物技术
- 癌症治疗
背景情况:
- 化学抗原受体 (CAR) 是设计用于治疗应用的免疫细胞重定向的受体.
- CAR 具有独特的域,对于识别抗原,激活 T 细胞和提供共刺激信号至关重要.
研究的目的:
- 描述CARs在免疫细胞重编程中的基本结构和功能.
- 概述产生和利用自主性CAR T细胞用于癌症治疗的过程.
主要方法:
- 将CARcDNA与T细胞基因组进行基因整合.
- 从患者外周血液中分离和扩张自身T细胞.
- 向接受者注射工程化CAR T细胞以消除瘤.
主要成果:
- 通过CARs成功重新编程免疫细胞.
- 能够向瘤的功能性自主T细胞的产生.
- 在接受者体内证明CAR T细胞扩张,以获得持续的治疗效果.
结论:
- 在采用免疫疗法方面,CAR技术代表了重大进步.
- 自主 CAR T 细胞治疗提供了个性化的癌症治疗方法.
