关于组合癌症治疗的设计
James H Doroshow1, Richard M Simon2
1Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD, USA; Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Cell
|December 16, 2017
概括
结合性癌症治疗显示出有限的临床协同作用. 研究表明,即使成功的治疗方法也经常通过单独的药物效应而不是组合的相互作用,挑战目前的癌症药物开发方法.
科学领域:
- 癌症学
- 药理学
- 翻译医学
背景情况:
- 组合疗法是治疗人类恶性瘤的标准.
- 寻求协同药物相互作用以提高治疗疗效.
研究的目的:
- 评估在体外观察到的协同抗癌药物相互作用的临床转化.
- 要确定组合治疗的成功是由于药物的协同作用还是独立作用.
主要方法:
- 对细胞培养数据进行协同药物相互作用的分析.
- 对小鼠模型和组合疗法的临床试验结果的审查.
主要成果:
- 在体外协同作用的药物相互作用很少转化为临床疗效.
- 结合疗法的成功往往是由单个药物的附加效应解释的.
- 临床结果并不总是支持体外协同效应的发现.
结论:
- 实验室协同作用的抗癌药物相互作用的临床意义值得怀疑.
- 独立的药物活动更有可能解释成功的组合疗法.
- 对结合癌症治疗的临床前模型和临床试验分析进行重新考虑是有必要的.
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