对高血压的遗传倾向和生活方式因素:与中年血压水平和心血管事件的关联
在PubMed上查看摘要
概括
此摘要是机器生成的。健康的生活方式显著降低血压 (BP) 和心血管疾病 (CVD) 的风险, 无论遗传倾向. 改变生活方式可以抵消高血压及其相关健康后果的遗传风险因素.
科学领域
- 心血管健康
- 遗传学
- 公共卫生
背景情况
- 高血压是导致心血管疾病的主要危险因素,
- 遗传因素和生活方式都会导致血压升高.
- 了解生活方式如何影响不同遗传倾向的个体的血压和心血管疾病风险至关重要.
研究的目的
- 确定健康的生活方式因素是否可以减轻高血压遗传风险对心血管疾病 (CVD) 风险的影响.
- 量化遗传风险得分,生活方式得分,血压水平和发生心血管疾病之间的关联.
主要方法
- 在277,005名没有先前心血管疾病的英国生物库参与者中,使用314个BP位点开发了高血压的遗传风险评分.
- 在招聘时评估了生活方式因素 (BMI,饮食,体力活动,酒精,吸烟,摄入量).
- 线性和考克斯回归模型分析了遗传风险,生活方式得分,血压和发生心血管疾病之间的关联.
主要成果
- 无论遗传血压风险如何,健康生活方式的得分与较低的静脉血压和扩张血压以及心血管疾病事件的减少有很强的相关性.
- 在所有遗传风险组中,有利的生活方式的个体血压显著降低 (3.5- 3. 6 mm Hg降低).
- 在所有遗传风险层中,健康的生活方式降低了30-33%的心血管疾病风险.
结论
- 全民生活方式修改策略对于降低血压和降低心血管疾病风险是有效的.
- 生活方式的干预可以抵消对高血压的遗传倾向.
- 披露遗传血压风险对个性化风险分层的影响需要仔细考虑.
相关概念视频
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