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可变形的空心周期性半孔有机纳米囊可显著改善细胞吸收
Zhaogang Teng1,2, Chunyan Wang1, Yuxia Tang1
1Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University , Nanjing, 210002 Jiangsu, P. R. China.
Journal of the American Chemical Society
|December 28, 2017
概括
研究人员开发了新型可变形的空心周期性半孔有机 (HPMO) 纳米囊,以增强细胞吸收. 这些灵活的纳米载体显著提高了癌症治疗应用中的药物输送效率.
科学领域:
- 材料科学
- 纳米技术
- 生物医学工程
背景情况:
- 在药物输送和瘤治疗中,
- 细胞吸收受到粒子变形的严重影响.
- 合成可变形的半孔材料仍然是一个重大挑战.
研究的目的:
- 合成新型可变形空心周期性半孔性有机 (HPMO) 纳米囊.
- 研究可变性对细胞吸收和药物输送的影响.
- 评估这些纳米囊在癌症治疗中的潜力.
主要方法:
- 使用优选蚀刻方法合成HPMO纳米.
- 纳米的特性 (尺寸,表面积,孔径,外厚度,Young的模量).
- 使用液体细胞电子显微镜评估MCF-7细胞的细胞吸收.
- 用多克索鲁比辛 (DOX) 进行药物输送评估.
主要成果:
- 成功合成具有均大小,高表面积和大孔积的可变形HPMO纳米囊.
- 与固体对应物 (251 MPa) 相比,HPMO纳米具有显著较低的扬模量 (3.95 MPa),这表明其灵活性很高.
- 可变形的HPMO通过改变形态来提高细胞吸收的26倍,从而促进进入MCF-7细胞.
- 含有DOX的HPMO纳米囊对MCF-7细胞产生强烈的杀死作用.
结论:
- 新的优选蚀刻方法使得可变形HPMO纳米的首次合成成为可能.
- HPMO的内在灵活性显著增强了细胞内化.
- 这些可变形的HPMO纳米囊对先进的药物输送和癌症治疗有很大的前景.
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