水解婴儿配方与常规配方对1型糖尿病风险的影响:TRIGR随机临床试验
, Mikael Knip1,2, Hans K Åkerblom1
1University of Helsinki, Helsinki, Finland.
JAMA
|January 4, 2018
概括
在高风险婴儿中使用水解奶粉并没有降低1型糖尿病的发生率. 这项研究表明,目前关于预防1型糖尿病的婴儿饮食建议不需要修订.
科学领域:
- 儿童内分泌学
- 免疫学
- 营养科学
背景情况:
- 早期接触完整的饮食蛋白质可能会增加1型糖尿病的风险.
- 经过大量水解的配方不含完整的蛋白质,因此可能具有保护作用.
研究的目的:
- 调查是否使婴儿接受大量水解配方可以降低1型糖尿病的累积发病率.
- 评估早期婴儿养对高危人群1型糖尿病发展的长期影响.
主要方法:
- 一项国际双盲随机临床试验涉及2159名高危婴儿.
- 婴儿被随机分配给广泛化素配方或常规配方.
- 长期随访 (中位数为11. 5年) 评估了1型糖尿病诊断和不良事件.
主要成果:
- 在水解配方组 (8. 4%) 和常规配方组 (7. 6%) 中,1型糖尿病的累积发病率相似.
- 1型糖尿病的调整后危险比为1.1 (95% CI,0. 8至1. 5;P=.46).
- 诊断时的中位数年龄或不良反应 (上呼吸道感染) 的频率没有显著差异.
结论:
- 将有1型糖尿病风险的婴儿奶为水解奶粉并没有降低该疾病的累积发病率.
- 这些发现不支持修订目前的预防风险婴儿1型糖尿病的饮食建议.
- 进一步的研究可能会探索其他早期暴露或干预措施.
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