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Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
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肝细胞癌

Alejandro Forner1, María Reig1, Jordi Bruix1

  • 1Barcelona Clinic Liver Cancer group, Liver Unit, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.

Lancet (London, England)
|January 9, 2018
PubMed
概括

通过超声监测在肝硬化患者中早期发现肝细胞癌 (HCC) 可以及时治疗. 目前的疗法包括切除,移植,切除,化学栓塞以及针对性药物如索拉费尼布.

科学领域:

  • 肝病学
  • 癌症学
  • 胃肠病学

背景情况:

  • 肝细胞癌 (HCC) 是肝硬化患者常见的并发症.
  • 早期诊断HCC对于有效治疗至关重要,通常通过半年一次的超声波监测来实现.

研究的目的:

  • 总结支持当前临床实践对HCC管理的科学证据.
  • 讨论需要进一步研究的HCC治疗领域.

主要方法:

  • 对当前HCC治疗指南的科学证据的审查.
  • 讨论治疗策略,包括切除,移植,切除,化学栓塞和全身疗法.

主要成果:

  • 切除是保持肝功能的单独瘤的最佳选择.
  • 肝移植适用于符合米兰标准的患者.
  • 图像导向的切除,化学栓塞和全身药物 (sorafenib,lenvatinib,regorafenib) 在特定的HCC阶段和患者形状上是有效的.

结论:

  • 目前的证据支持基于瘤阶段和患者状况的肝细胞癌的监测和各种治疗策略.
  • 需要进一步的研究来完善治疗方案并改善晚期HCC的结果.

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