饮食中的三糖增强了流行性Clostridium difficile的毒性
J Collins1, C Robinson2, H Danhof1
1Baylor College of Medicine, Department of Molecular Virology and Microbiology, One Baylor Plaza, Houston, Texas 77030, USA.
Nature
|January 9, 2018
概括
两个Clostridium difficile菌株 (RT027和RT078) 进化以代谢糖三糖. 这种与食品添加剂三糖相关的适应可能解释了它们的流行率和毒性增加.
科学领域:
- 微生物学
- 传染性疾病
- 分子生物学
背景情况:
- 困难菌感染 (CDI) 是一个主要的医疗相关病原体.
- 对于高毒性Clostridium difficile核型 (RT027和RT078) 的出现尚不完全了解.
研究的目的:
- 调查流行性Clostridium difficile菌株的出现和高毒性的机制.
- 确定三糖代谢在Clostridium difficile进化中的作用.
主要方法:
- 流行性Clostridium difficile核型的基因组分析
- 生物化学测试以评估三的代谢.
- 在体内感染Clostridium difficile的小鼠模型.
主要成果:
- 由于特雷抑制剂的突变,RT027菌株具有增加的特雷敏感性.
- 在小鼠模型中,饮食中摄入的三糖增强了RT027的毒性.
- RT078菌株具有使其在低度下生长的基因集群.
结论:
- 获得三糖代谢途径是流行性Clostridium difficile菌株的关键适应.
- 饮食中增加的三糖可能是这些菌株的选择,有助于它们的出现和高毒性.
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