随机对照试验:对预防心力衰竭的影响
Erin J Howden1,2,3, Satyam Sarma1,2, Justin S Lawley1,2
1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (E.J.H., S.S., J.S.L., M.O., W.C., D.S., M.A.U., B.D.L.).
Circulation
|January 10, 2018
概括
在中年时定期炼可以显著改善心肺健康并减少心脏硬. 这种干预可以通过抵消与年龄相关的硬度增加来预防心力衰竭.
科学领域:
- 心脏病学
- 运动生理学
- 预防医学
背景情况:
- 中年人的身体状况不佳是心力衰竭的重要危险因素,特别是心力衰竭的副类型,称为心力衰竭与保留射出分数 (HFpEF).
- 左心室硬度增加是久坐衰老的后果,可能是导致HFpEF的机制.
- 这项研究研究了结构化的运动计划对健康的中年成年人肌肉硬度的影响.
研究的目的:
- 确定两年监督高强度炼对中年久坐者左心室硬度的影响.
- 评估运动训练是否可以与心脏力学变化一起改善心脏呼吸能力 (最大氧气吸收).
- 评估运动减轻与年龄相关的心脏硬度增加和降低HFpEF风险的潜力.
主要方法:
- 一项前性随机对照试验,涉及61名健康,久坐不动的中年参与者 (平均年龄为53岁).
- 参与者被分配到两年监督的高强度运动训练 (n=34) 或注意力控制组 (n=27).
- 使用右心导管和三维心声学与预加载操纵来分析透气压力-体积关系来评估左心室 (LV) 刚性. 测量最大的氧气吸收量 (Vo2max),以量化体能水平.
主要成果:
- 与对照组相比,运动训练组的最大氧气摄入量 (Vo2max) 显著增加了18% (P< 0. 001).
- 运动组的 LV 刚度显著降低 (P=0. 0018),由终端透气压与体积关系的向下转移表明,而对照组没有变化 (P=0. 83).
- 在没有改变肺毛细管压力的情况下,运动训练增加了 LV 终端透析体积,从而提高了给定充填压力的冲击体积 (P=0. 007).
结论:
- 在此前久坐不动的中年人群中,两年监督的运动训练有效改善了心肺健康状况,并降低了心脏硬度.
- 通过预防随着年龄的增长而导致的心脏硬的有害增加,定期运动可以提供一种预防心力衰竭的策略.
- 这些发现凸显了运动干预措施在老年人群中增强心血管健康和预防心脏病的潜力.
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