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陈和沈关于"外体微RNA转移到巨细胞中介细胞后调节"的文章

Weiqian Chen1, Zhenya Shen2

  • 1Department of Cardiovascular Surgery of the First Affiliated Hospital, Institute for Cardiovascular Science, Soochow University, Suzhou, China (W.C., Z.S.).

Circulation
|January 10, 2018
PubMed
概括

No abstract available in PubMed .

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...