神经素控制成熟的双形性神经元的可塑性
Michael P Hart1, Oliver Hobert1
11Department of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York, USA.
Nature
|January 12, 2018
概括
在C. elegans中,成年男性在释放GABA的DVB神经元中表现出经验依赖的神经元可塑性,改变交配行为. 这种性二态可塑性涉及神经元的增加,由神经素和神经蛋白调节.
科学领域:
- 神经科学
- 发育生物学
- 行为生物学
背景情况:
- 神经元可塑性对发育和成年至关重要,它影响了突触结构和神经元连接.
- 性别对神经元可塑性的影响在很大程度上仍未被探索,特别是在形态层面.
研究的目的:
- 调查性行为对神经元可塑性的作用.
- 阐明神经元中体验依赖的形态变化的机制.
主要方法:
- 使用了Caenorhabditis elegans作为一个模型生物.
- 对释放GABA的DVB神经元进行了体验依赖性和性二态可塑性的检查.
- 研究了神经元前神经素和神经元后神经素在神经元外生长中的作用.
主要成果:
- 成年雄性C. elegans中的DVB神经元显示神经元的随机和动态增加.
- 这种神经元的增加导致了突触重新连接和DVB神经元中的功能开关.
- 通过神经激素促进神经细胞外生,而通过神经激素抑制,揭示了新的相互作用.
结论:
- 性别显著影响神经元的可塑性,导致DVB神经元的性二态形态变化.
- 经验和 postsynaptic 活动可以改变 DVB 神经元功能和雄性交配行为.
- 神经和神经介导神经元可塑性的保护机制,这与人类疾病有关.
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