精确编辑肠道微生物群改善大肠炎
Wenhan Zhu1, Maria G Winter1, Mariana X Byndloss2
1Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Nature
|January 12, 2018
概括
酸盐治疗可以通过向特定的微生物通路,防止炎症期间有害的肠道细菌扩散. 这种精确编辑肠道微生物群可以减少小鼠的肠道炎症严重程度.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎症性胃肠道疾病与肠道失调有关,其特征在于随机无氧细菌的增加,如Enterobacteriaceae (蛋白质细菌).
- 这种失生症涉及特定的微生物呼吸道,依赖于辅因子,在炎症期间活跃.
研究的目的:
- 调查 tungstate 治疗是否可以在肠道炎症期间防止 Enterobacteriaceae 的失生扩张.
- 评估 tungstate 在炎症和恒温条件下对微生物群落的影响.
- 评估 tungstate介导的微生物群编辑在减少肠道炎症方面的治疗潜力.
主要方法:
- tungstate 的治疗是给予大肠炎的小鼠模型.
- 在炎症和恒温条件下分析了微生物群组成.
- 研究了tungstate对依赖辅因子的微生物呼吸道的影响.
主要成果:
- 在肠道炎症期间,tungstate治疗有效地防止了Enterobacteriaceae的失生扩张.
- 酸可以选择性地抑制特定于炎症的微生物呼吸道.
- 在恒温的条件下,酸会对微生物群的组成造成极小的改变.
- 通过tungstate编辑微生物群显著降低了结肠炎模型中的肠道炎症的严重程度.
结论:
- 酸在炎症期间作为肠道微生物群的精确编辑工具.
- 用酸盐准依赖辅因子的途径可以改善与失生症相关的炎症.
- 这种方法为炎症性肠道疾病提供了潜在的治疗策略.
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