骨髓发育原体的调节是训练免疫的组成部分
Ioannis Mitroulis1, Klara Ruppova1, Baomei Wang2
1Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.
Cell
|January 13, 2018
概括
经过训练的免疫通过调节造血干细胞和原生细胞 (HSPC) 来增强髓状细胞的反应. 这包括增加骨髓形成,改善对二次挑战和化疗的反应.
科学领域:
- 免疫学
- 血液学
- 细胞生物学
背景情况:
- 训练有素的天生的免疫力增强了骨髓细胞对次要挑战的反应.
- 培训免疫的基础机制,特别是有关髓质细胞寿命的机制,仍然不完全理解.
- 血造干细胞和原始细胞 (HSPC) 对于骨髓细胞的产生至关重要.
研究的目的:
- 研究HSPC在训练免疫中的作用.
- 确定受训免疫是否会调节骨髓中的骨髓前代细胞.
- 了解训练免疫力对骨髓发育和宿主防御的影响.
主要方法:
- 用于诱导小鼠受过训练的免疫力.
- 骨髓原体扩张和相关分子信号的分析 (例如IL-1β,GM-CSF).
- 在骨髓原体中对代谢适应 (葡萄糖代谢,胆固醇生物合成) 的评估.
- 评估宿主对二次挑战 (LPS) 和化疗诱导的骨髓抑制的反应.
主要成果:
- 在小鼠中,β- 葡萄糖诱导了骨髓系祖先的扩张.
- 这种扩张与HSPCs的先天免疫媒介信号和代谢适应性增加有关.
- 被训练的免疫诱导骨髓形成改善了对LPS挑战的反应,并防止了化疗诱导的骨髓抑制.
- 骨髓中髓原体的调节被确定为训练免疫的关键组成部分.
结论:
- 经过训练的免疫通过造血干细胞和原生细胞 (HSPC) 的调节起作用.
- 骨髓骨髓原体适应是训练免疫的组成部分,它已知的机制超出了外围骨髓细胞功能.
- 这一发现为先天免疫刺激的长期影响和潜在的治疗策略提供了新的见解.
相关概念视频
What is the Immune System?
133.3K
Overview
133.3K
Components of Language
836
Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
836
Components of Stress
559
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
Interestingly, the hidden cube faces also experience these stresses, equal and...
559
Integration by Parts: Indefinite Integrals
289
Integration by parts is a fundamental technique in calculus for evaluating integrals involving the product of two functions. It is particularly useful when direct integration is not feasible. The method is based on the product rule for differentiation, which states that the derivative of a product equals the derivative of the first function times the second, plus the first function times the derivative of the second. By integrating this identity and rearranging terms, the integration by parts...
289
Integration by Parts: Definite Integrals
95
Definite integrals involving the product of two functions over a fixed interval can be evaluated using integration by parts. This method rewrites the integral as the difference of a product evaluated at the endpoints and a remaining definite integral that is often simpler to compute.A representative example is the definite integral of the inverse tangent function. Since there is no direct integration formula for arctan x, the integrand is rewritten as a product of arctan x and the...
95
Humoral Immune Responses
84.2K
Overview
84.2K


