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在NT5C2突变复发性急性淋巴细胞白血病中的克隆进化机制

Gannie Tzoneva1, Chelsea L Dieck1, Koichi Oshima1

  • 1Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA.

Nature
|January 18, 2018
PubMed
概括

在NT5C2基因驱动器中获得功能突变通过赋予化疗耐药性导致急性淋巴细胞白血病 (ALL) 复发. 通过向 purin 合成,抑制 IMPDH 是对治疗 NT5C2 突变 ALL 的有前途的.

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