控制运动速度和步态的中脑回路
V Caggiano1, R Leiras1,2, H Goñi-Erro1,2
1Mammalian Locomotor Laboratory, Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.
Nature
|January 18, 2018
概括
科学家发现特定的脑干神经元控制动物的速度和步伐. 中脑中的质激发性神经元 (GlutNs)
科学领域:
- 神经科学
- 动物的行为
- 发动机控制
背景情况:
- 运动对于动物的生存和行为至关重要.
- 大脑干结构控制运动, 但特定的神经元基质仍然不清楚.
- 不同的行为 (例如,探索,逃跑) 需要不同的速度和步态.
研究的目的:
- 阐明运动中的速度和步态选择的神经机制.
- 确定特定的中脑核和神经元类型参与控制运动行为.
- 在上下文依赖的运动中区分不同神经元群体的作用.
主要方法:
- 在小鼠体内的电生理学.
- 通过光遗传来操纵神经元活动.
- 对神经元连接和激活动态的分析.
- 运动行为测试,包括速度和步态分析.
主要成果:
- 形核 (CnF) 和脚型核 (PPN) 中的葡萄糖激发性神经元 (GlutNs) 控制运动.
- 在CnF和PPN中,GlutN对缓慢的,交替步行的运动有所贡献.
- CnF GlutN 独特地控制高速,同步步行的运动.
- PPN和CnFGlutN的独特激活动态和连接模式分别支持探索和逃跑行为.
结论:
- 两个中脑核,CnF和PN,有不同的控制运动的GlutN群体.
- 这些GlutN群体协同选择环境依赖的运动行为,如探索和逃跑.
- 这些发现揭示了基于行为需求的适应性运动控制的神经回路.
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