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通过多分析剂血液检测检测和定位可切除的癌症
Joshua D Cohen1,2,3,4,5, Lu Li6, Yuxuan Wang1,2,3,4
1Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
概括
通过分析蛋白质和无细胞DNA, 可以检测出八种常见的癌症. 这种早期癌症检测具有很高的敏感性和特异性,有助于及时诊断和治疗.
科学领域:
- 癌症学
- 生物标志物发现
- 分子诊断
背景情况:
- 早期发现癌症可以显著提高患者的生存率.
- 目前的查方法对于几种常见的癌症是有限的.
- 循环中的瘤DNA和蛋白质是非侵入性癌症检测的有希望的生物标志物.
研究的目的:
- 评估CancerSEEK的性能, 这是一种用于检测多种常见癌症的新型血液测试.
- 在非转移性癌症患者中评估CancerSEEK的敏感性和特异性.
- 确定CancerSEEK能够定位检测到的癌症的来源.
主要方法:
- 癌症SEEK对1005名临床发现的非转移性癌症 (卵巢,肝脏,胃,胰腺,食道,结肠,肺,乳腺) 的患者进行了研究.
- 这项测试分析了无细胞DNA中的循环蛋白质水平和突变.
- 对812个健康对照组进行了评价.
主要成果:
- 癌症SEEK检测到八种常见癌症的中位数为70%.
- 对于目前缺乏查选择的五种癌症类型,敏感度在69%至98%之间.
- 具体性超过99%,在812名健康对照中,只有7人呈阳性.
- 在83%的患者中,癌症SEEK局部化到少数解剖部位.
结论:
- 通过单一的血液检测,CancerSEEK显示出高灵敏度和特异性来检测多种常见的癌症.
- 这项测试对缺乏现有查方法的癌症具有特别的前景.
- 能够定位癌症的起源进一步提高了CancerSEEK在早期诊断中的临床效用.
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