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Updated: Feb 15, 2026

A Protein Preparation Method for the High-throughput Identification of Proteins Interacting with a Nuclear Cofactor Using LC-MS/MS Analysis
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A Protein Preparation Method for the High-throughput Identification of Proteins Interacting with a Nuclear Cofactor Using LC-MS/MS Analysis

Published on: January 24, 2017

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人类PRC2及其辅因子AEBP2和JARID2的结构

Vignesh Kasinath1,2, Marco Faini3, Simon Poepsel1,2

  • 1QB3 Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|January 20, 2018
PubMed
概括

聚抑制复合体2 (PRC2) 甲基化对于发育至关重要. 低温EM结构揭示了JARID2和AEBP2如何通过模仿基因组尾巴来调节PRC2活动,从而提供了对复杂结构和调节的见解.

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