对于外科和跨导管生物假体动脉的结构退化的标准化定义
Danny Dvir1, Thierry Bourguignon2, Catherine M Otto1
1University of Washington Medical Center, Seattle (D.D., C.M.O., G.B.M., M.R., J.M.M., G.S.A.).
Circulation
|January 24, 2018
概括
为了改善研究和临床护理,建议对生物假体退化的标准化定义. 这些标准旨在提高门耐用性研究的可比性和解释性,以获得更好的患者结果.
科学领域:
- 心血管医学
- 生物材料科学
- 临床研究方法
背景情况:
- 由于结构性变,生物假体心脏的长期耐用性有限.
- 由于缺少对退化的标准化定义,比较生物假体的耐用性是具有挑战性的.
- 这种缺乏标准化阻碍了手术植入和透气管之间的准确比较.
研究的目的:
- 提出生物假体退化的实用和标准化定义.
- 为退化门的临床和成像后续评估提供建议.
- 提高生物假体损坏患者的研究和临床治疗质量.
主要方法:
- 由VIVID (Valve-in-Valve国际数据) 组开发了退化的标准化定义.
- 确定临床和成像后续评估的时间标准.
- 专注于在未来的临床试验中使用客观和严格的标准.
主要成果:
- 提出生物假体退化的标准定义.
- 根据已定义的退化标准,推随访时间.
- 一个客观评估的框架来提高研究质量.
结论:
- 采用标准化的定义将提高生物假体的耐用性分析的可比性和解释性.
- 标准化标准将促进更强大的临床试验和提高患者护理.
- 心脏病学和手术界之间的合作对于实施这些标准至关重要.
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