非小细胞肺癌的生物学和治疗方法
Roy S Herbst1, Daniel Morgensztern2, Chris Boshoff1,3
1Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA.
Nature
|January 25, 2018
概括
在非小细胞肺癌 (NSCLC) 治疗方面取得了显著进展,但生存率,特别是转移性疾病,仍然很低. 进一步研究新疗法和组合对于改善患者的结果至关重要.
科学领域:
- 癌症学
- 翻译医学
- 癌症生物学
背景情况:
- 不小细胞肺癌 (NSCLC) 治疗在过去20年中取得了进展.
- 对NSCLC生物学和瘤进展的了解有所增加.
- 早期检测和多模式护理策略有所改善.
研究的目的:
- 审查非小细胞肺癌 (NSCLC) 治疗的最新进展.
- 突出针对性治疗和免疫治疗的影响.
- 强调在NSCLC药物开发方面需要继续进行研究.
主要方法:
- 在过去二十年中,对NSCLC治疗的关键进展进行了回顾.
- 分析小分子氨酸激酶抑制剂和免疫治疗的影响.
- 对目前转移性NSCLC的生存率和挑战进行评估.
主要成果:
- 小分子氨酸激酶抑制剂和免疫疗法在特定的NSCLC患者中提供生存益处.
- 尽管有进展,但NSCLC的整体治愈和存活率,特别是转移性疾病,仍然不理想.
- 在扩大治疗效益到更广泛的患者群体方面,仍然存在重大未满足的需求.
结论:
- 对新型药物和组合疗法的持续研究对于NSCLC至关重要.
- 改善NSCLC的结果需要将临床益处扩展到更多的患者.
- 推进NSCLC治疗需要专注于克服转移的局限性.
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